Posted by forex | Posted in Professor Raymond Gosling | Posted on 10:03:00 am
Raymond Gosling
aymond Gosling (born 1926) is a distinguished scientist who worked with both Maurice Wilkins and Rosalind Franklin at King's College London in deducing the structure of DNA, under the direction of Sir John Randall. His other KCL colleagues included Alex Stokes and Herbert Wilson.
Professor Raymond Gosling for 2003 "DNA at King's - the continuing story: 50th anniversary of the discovery of the structure of DNA"
He was born in 1926 and attended school in Wembley. He studied physics at University College London from 1944 to 1947 and became a hospital physicist at the King’s Fund and Middlesex Hospital between 1947 and 1949 before joining King's College London as a research student.
Work at King's and DNA
At King's College London, Gosling worked on X-ray diffraction with Maurice Wilkins, analyzing samples of DNA which they prepared by hydrating and drawing out into thin filaments and photographing in a hydrogen atmosphere.
Gosling was then assigned to Rosalind Franklin when she joined King's College London in 1951. Together they produced the first X-ray diffraction photographs of the "form B" paracrystalline arrays of highly hydrated DNA. She was his academic supervisor. During the next two years, the pair worked closely together to perfect the technique of x-ray diffraction photography of DNA and obtained at the time the sharpest diffraction images of DNA. This work led directly to the 1962 Nobel Prize for Physiology or Medicine being awarded to Francis Crick, James D. Watson and Maurice Wilkins. Gosling was the co-author with Franklin of one of the three papers published in "Nature" in April 1953.
Gosling briefly remained at King's College London following the completion of his thesis in 1954 before lecturing in physics at Queen’s College, University of St Andrews, and at the University of the West Indies.
Work at Guy's Hospital
He returned to the UK in 1967 and became Lecturer and Reader at Guy's Hospital Medical School, and Professor and Emeritus Professor in Physics Applied to Medicine from 1984. Here he helped develop the underlying basic medical science and technology for haemodynamic doppler ultrasound vascular assessment in the Non Invasive Angiology Group, and set up the clinical Ultrasonic Angiology Unit.
Gosling has served on numerous committees of the University of London, notably relating to radiological science, and still retains an active professional involvement in medical physics
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http://www.packer34.freeserve.co.uk/rememberingfranciscrickacelebration.htm
This is a reproduction of a 'funeral card' produced in jest by the late Rosalind Franklin and Raymond Gosling (see signatures in the image) in 1952 to decline the Maurice H.F. Wilkins's and Crick-Watson's ideas of a DNA helix as being supported by either their own X-ray data or their analysis (e.g., RF's and RG's). Apparently, when they wrote the card, unlike M.H.F.W and C-W, the two authors were unaware of the Chargaff's rules.
The text in the original card is verbatim: "IT IS WITH GREAT REGRET THAT WE HAVE TO ANNOUNCE THE DEATH ON FRIDAY, 18TH JULY 1952 OF D.N.A HELIX (CRYSTALLINE). DEATH FOLLOWED A PROTRACTED ILLNESS WHICH AN INTENSIVE COURSE OF BESSELISED INJECTIONS HAD FAILED TO RELIEVE. A MEMORIAL SERVICE WILL BE HELD NEXT MONDAY OR TUESDAY. IT IS HOPED THAT DR. M.H.F. WILKINS WILL SPEAK IN MEMORY OF THE LATE HELIX (Signed) Rosalind Franklin and Raymond Gosling. "
This may appear to be intended as a joke informally rejecting the DNA double helix configuration: Dr. Franklin and Raymond Gosling wrote this in jest, but they really meant it at the time that the idea of a helix B-DNA (or A-DNA) model would be either unproven or unlikely. They were incorrect about the absence of the helix structure of DNA, but they were nevertheless correct about the fact that the B-DNA pattern of highly hydrated, in vivo or in vitro, DNA is not corresponding to a crystalline DNA (as explicitly stated in parenthesis in this joke funeral card photo), but to a paracrystal, that is, to a partially ordered (quasi) lattice of DNA fibers with more than 20% disordering of the DNA fibers and dynamically attached water molecules and ions,One shouldn't be fooled by the jocular tone of the funeral note: RF and RG really meant --at the time--what they said only in jest... In fact, their intention was that all M.H.F.W's attempts to say that a helical DNA structure might be supported by their own, high-quality, X-ray patterns shouldn't be taken at all seriously.
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